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Duodenum Concentrate A Natural Alternative to Antacids

Early Reports of Effective Oral Use of Duodenum Concentrates

The use of raw duodenum concentrate as a natural antacid in gastrointestinal therapy is not new. As early as 1945, clinical trials showed effective oral use of duodenum concentrates in patients suffering from:

  • Peptic Ulcer

  • Duodenal Ulcer

  • Ulcerative Colitis

This natural therapy does not cause constipation and is free from side effects that may occur with traditional medications.

Enterogastrone from Duodenum Reduces Acid Production

In 1886 the phenomenon was noted that fat, added to a meal, inhibited stomach acid secretion. Experiments later revealed that this inhibition of stomach acid did not occur until the fat entered the duodenum. Careful research showed that the effect came from a substance released into the bloodstream in response to entry of fat into the duodenum. The substance was named "enterogastrone" to indicate that it came from the duodenum, but affected the stomach.

Using daily intravenous injections of potent concentrates of enterogastrone, physicians saw a high incidence of permanent relief in peptic ulcer patients. However, no effect was noted when the concentrate was used orally.

Properly Prepared Whole Duodenum Substance Is Effective for Oral Use

While pure enterogastrone was not effective for oral use, it was later demonstrated that a powder made from whole duodenum was effective. The powder made from desiccated and defatted porcine duodenum was prepared at physiological temperature (37°C) to prevent the substance from being autolysed during the manufacturing process. In preliminary studies, many patients obtained symptomatic relief within 24 to 48 hours after therapy was initiated. The effect thereafter was continuous, which prompted the theory that the effective agent was present in whole duodenum as a precursor which the system elaborated into the active agent upon ingestion.

Research also indicates that the preparation of whole duodenum may contain an anti-ulcer factor as well as substances that protect the mucosa from autolysis by proteolytic enzymes.

Efficacy of this therapy was indicated in the following studies.

  • Cresen K and Steigmann F, Gastroenterology, 33:359, 1960.
    This double blind study of 33 peptic ulcer patients showed better control of symptoms as compared to a placebo. Results suggested that this preparation is "at least as good as popular antacids and antispasmodics and has no toxic or side effects."

  • Ivy AC, Grossman M, Federation Proc., 5:37, 1946.
    "Crude extracts of duodenal mucosa have been found effective in preventing Mann-Williamson ulcers when given by mouth."

  • Rivers AB, Am J Dig Dis, 2:189, 1935.
    "Duodenal extract was effective in the treatment of benign peptic lesions; rapid healing demonstrated by x-ray."

  • Greengard H, Atkinson AJ, Ivy AC, Gastroenterology, 7:625, 1946.
    "Anti-ulcer effect of oral duodenal concentrates may not be attributed to the action of enterogastrone as such in suppressing gastric acidity and motility, but another action of enterogastrone or another substance present in the concentrate may be responsible for the protection against ulcers. "

  • Krasnow S, Steigmann F, Hardt LL, Am J Dig Dis, 17:242, 1950.
    "Duodenum concentrate relieves symptoms with rapid neutralization of acidity and with an increase in the total volume of gastric secretion."

  • Cheney G, Medical Management of Gastrointestinal Disorders, Yearbook Publishers, 1950.
    "Duodenum increases the resistance of the mucosa to irritation and apparently promotes the healing of the bowel by supplying some anti-ulcer factor."

  • Gill AM, Lancet 2:202, 1945.
    "Oral treatment with whole desiccated and defatted duodenum was effective in the treatment of ulcerative colitis."

  • Freidman MHF, Haskell BF, Gastroenterology, 11:833, 1948.
    "Oral administration of hog intestine extracts gave beneficial results in patients with ulcerative colitis...23 patients were followed for one year. Only 2 of these patients failed to respond to treatment."

  • Raimondi PJ, Permanente Found Med Bull, 8:4, October 1950.
    "Duodenum concentrate effectively decreases the frequency of recurrence of symptoms even in patients who had formerly shown the highest frequency of exacerbations."

Side Effects Associated with Ulcer Medications

Medical treatment of ulcers focuses primarily on use of antacids and H2 receptor-antagonists such as cimetidine (Tagamet) and ranitidine (Zantac), which block production of gastric acid. While these approaches reduce acidity and allow healing of the inflamed or ulcerated area, they deprive the body of the beneficial effects of stomach acid. As a result:

  • Digestion is impaired.
  • The body loses its protection against bacteria such as salmonella, shigella and E. coli.
  • Candida albicans concentrations increase, even in normally sterile portions of the gastrointestinal tract.
  • Mucus synthesis and secretion decrease.
  • Microvilli become blunt and sparse.
  • Enzyme activity of duodenal enterocytes is altered.
  • Changes in the ultrastructure of gastrointestinal epithelium may occur.

Although cimetidine is very effective in healing peptic ulcers, there is a higher relapse rate if maintenance treatment is discontinued than with any other anti-ulcer treatment.

Duodenum Concentrate Acts as a pH Control Agent for Pancreatic Enzymes

An alkaline environment is required for pancreatic enzyme activity in the intestines. Duodenum concentrate supplements increase the secretion of the duodenal hormone secretin which stimulates bicarbonate secretion by the pancreas. These bicarbonate secretions are the primary method of alkalinizing the small intestine and, therefore, play a major role in proper pancreatic enzyme activity. Duodenum supplements would, therefore, be useful for patients being given oral pancreatic enzyme replacement therapy (Pan 5X or Pan 10X).

Whole duodenum concentrate also contains the enzymes normally found in the duodenum, 80% pure protein, 10% animal mucin, and it is a rich source for the intrinsic anti-pernicious anemia factor.

Healing the Digestive Tract Naturally

In addition to duodenum concentrate, other natural products can help protect and heal the gastrointestinal tract:

  • Kassir AZ, Irish Med J, 1985, 78:153-156.
    "When the therapeutic effect of deglycyrrhizinated licorice (DGL) was compared to that of drug regimens in 874 patients with chronic duodenal ulcers, there was no significant difference in the healing rate of the four groups; however, there were fewer relapses in the DGL group."

  • Townsend Letter for Doctors, Jan 1993, p22.
    "In a review of 23 studies using gamma oryzanol, an extract of rice bran oil, therapeutic improvement was seen in 85% to 90% in a broad range of gastrointestinal disorders including stress-induced gastric and duodenal ulcers."

  • Nutrient Express, July 1993.
    "The amino-sugar N-Acetyl Glucosamine (NAG) and the proteoglycan structures it builds are especially important in the intestine because they form the protective mucous layer and cellular cement that regulates intestinal permeability."

These natural healers are found in  DGL Xtra.

WARNING: This publication and the product contained herein have not been approved or evaluated by the Food and Drug Administration. This publication, and the product contained herein are not intended to diagnose, treat, cure or prevent any disease. The product relates to nutritional support only.


Duodenum Concentrate - Natural Antacid

Product No. 2010 Fill Size: 90 Capsules

Each capsule contains:

Raw Porcine Duodenum Concentrate 425 mg.
Other ingredients: rice flour, magnesium stearate, gelatin.

The duodenum concentrate in this product is prepared by a special process that does not exceed physiological temperature (37°C). Guaranteed to be free of pesticides and synthetic hormones.

Therapeutic Use: Two to four capsules with each meal and at bedtime.

Maintenance: One capsule with each meal.

Price:  $13.00



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