Duodenum Concentrate A Natural Alternative to Antacids
Early Reports of Effective Oral Use of Duodenum Concentrates
The use of raw duodenum concentrate as a natural antacid in
gastrointestinal therapy is not new. As early as 1945, clinical trials
showed effective oral use of duodenum concentrates in patients suffering
This natural therapy does not cause constipation and is free from
side effects that may occur with traditional medications.
Enterogastrone from Duodenum Reduces Acid Production
In 1886 the phenomenon was noted that fat, added to a meal, inhibited
stomach acid secretion. Experiments later revealed that this inhibition
of stomach acid did not occur until the fat entered the duodenum.
Careful research showed that the effect came from a substance released
into the bloodstream in response to entry of fat into the duodenum. The
substance was named "enterogastrone" to indicate that it came
from the duodenum, but affected the stomach.
Using daily intravenous injections of potent concentrates of
enterogastrone, physicians saw a high incidence of permanent relief in
peptic ulcer patients. However, no effect was noted when the concentrate
was used orally.
Properly Prepared Whole Duodenum Substance Is Effective for Oral Use
While pure enterogastrone was not effective for oral use, it was
later demonstrated that a powder made from whole duodenum was effective.
The powder made from desiccated and defatted porcine duodenum was
prepared at physiological temperature (37°C) to prevent the substance
from being autolysed during the manufacturing process. In preliminary
studies, many patients obtained symptomatic relief within 24 to 48 hours
after therapy was initiated. The effect thereafter was continuous, which
prompted the theory that the effective agent was present in whole
duodenum as a precursor which the system elaborated into the active
agent upon ingestion.
Research also indicates that the preparation of whole duodenum may
contain an anti-ulcer factor as well as substances that protect the
mucosa from autolysis by proteolytic enzymes.
Efficacy of this therapy was indicated in the following studies.
Cresen K and Steigmann F, Gastroenterology, 33:359, 1960.
This double blind study of 33 peptic ulcer patients showed better
control of symptoms as compared to a placebo. Results suggested that
this preparation is "at least as good as popular antacids and
antispasmodics and has no toxic or side effects."
Ivy AC, Grossman M, Federation Proc., 5:37, 1946.
"Crude extracts of duodenal mucosa have been found effective in
preventing Mann-Williamson ulcers when given by mouth."
Rivers AB, Am J Dig Dis, 2:189, 1935.
"Duodenal extract was effective in the treatment of benign
peptic lesions; rapid healing demonstrated by x-ray."
Greengard H, Atkinson AJ, Ivy AC, Gastroenterology, 7:625,
"Anti-ulcer effect of oral duodenal concentrates may not be
attributed to the action of enterogastrone as such in suppressing
gastric acidity and motility, but another action of enterogastrone
or another substance present in the concentrate may be responsible
for the protection against ulcers. "
Krasnow S, Steigmann F, Hardt LL, Am J Dig Dis, 17:242,
"Duodenum concentrate relieves symptoms with rapid
neutralization of acidity and with an increase in the total volume
of gastric secretion."
Cheney G, Medical Management of Gastrointestinal Disorders,
Yearbook Publishers, 1950.
"Duodenum increases the resistance of the mucosa to irritation
and apparently promotes the healing of the bowel by supplying some
Gill AM, Lancet 2:202, 1945.
"Oral treatment with whole desiccated and defatted duodenum was
effective in the treatment of ulcerative colitis."
Freidman MHF, Haskell BF, Gastroenterology, 11:833, 1948.
"Oral administration of hog intestine extracts gave beneficial
results in patients with ulcerative colitis...23 patients were
followed for one year. Only 2 of these patients failed to respond to
Raimondi PJ, Permanente Found Med Bull, 8:4, October 1950.
"Duodenum concentrate effectively decreases the frequency of
recurrence of symptoms even in patients who had formerly shown the
highest frequency of exacerbations."
Side Effects Associated with Ulcer Medications
Medical treatment of ulcers focuses primarily on use of antacids and
H2 receptor-antagonists such as cimetidine (Tagamet) and ranitidine
(Zantac), which block production of gastric acid. While these approaches
reduce acidity and allow healing of the inflamed or ulcerated area, they
deprive the body of the beneficial effects of stomach acid. As a result:
- Digestion is impaired.
- The body loses its protection against bacteria such as salmonella,
shigella and E. coli.
- Candida albicans concentrations increase, even in normally
sterile portions of the gastrointestinal tract.
- Mucus synthesis and secretion decrease.
- Microvilli become blunt and sparse.
- Enzyme activity of duodenal enterocytes is altered.
- Changes in the ultrastructure of gastrointestinal epithelium may
Although cimetidine is very effective in healing peptic ulcers, there
is a higher relapse rate if maintenance treatment is discontinued than
with any other anti-ulcer treatment.
Duodenum Concentrate Acts as a pH Control Agent for Pancreatic
An alkaline environment is required for pancreatic enzyme activity in
the intestines. Duodenum concentrate supplements increase the secretion
of the duodenal hormone secretin which stimulates bicarbonate secretion
by the pancreas. These bicarbonate secretions are the primary method of
alkalinizing the small intestine and, therefore, play a major role in
proper pancreatic enzyme activity. Duodenum supplements would,
therefore, be useful for patients being given oral pancreatic enzyme
replacement therapy (Pan 5X or Pan 10X).
Whole duodenum concentrate also contains the enzymes normally found
in the duodenum, 80% pure protein, 10% animal mucin, and it is a rich
source for the intrinsic anti-pernicious anemia factor.
Healing the Digestive Tract Naturally
In addition to duodenum concentrate, other natural products can help
protect and heal the gastrointestinal tract:
Kassir AZ, Irish Med J, 1985, 78:153-156.
"When the therapeutic effect of deglycyrrhizinated licorice
(DGL) was compared to that of drug regimens in 874 patients with
chronic duodenal ulcers, there was no significant difference in the
healing rate of the four groups; however, there were fewer relapses
in the DGL group."
Jan 1993, p22.
Townsend Letter for Doctors,
"In a review of 23 studies using gamma oryzanol, an
extract of rice bran oil, therapeutic improvement was seen in 85% to
90% in a broad range of gastrointestinal disorders including
stress-induced gastric and duodenal ulcers."
"The amino-sugar N-Acetyl Glucosamine (NAG) and the
proteoglycan structures it builds are especially important in the
intestine because they form the protective mucous layer and cellular
cement that regulates intestinal permeability."
These natural healers are found in DGL Xtra.
WARNING: This publication and the product contained herein have not
been approved or evaluated by the Food and Drug Administration. This
publication, and the product contained herein are not intended to
diagnose, treat, cure or prevent any disease. The product relates to
nutritional support only.
Duodenum Concentrate - Natural Antacid
Product No. 2010 Fill Size: 90 Capsules
Each capsule contains:
Raw Porcine Duodenum Concentrate 425 mg.
Other ingredients: rice flour, magnesium stearate, gelatin.
The duodenum concentrate in this product is prepared by a special
process that does not exceed physiological temperature (37°C).
Guaranteed to be free of pesticides and synthetic hormones.
Therapeutic Use: Two to four capsules with each meal and at bedtime.
Maintenance: One capsule with each meal.
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