Stress is a term widely used in our fast-paced society. Job pressures, family arguments, financial pressures and deadlines are common examples of "stressors". Actually, a stressor may be anything which creates a disturbance, including exposure to heat or cold, environmental toxins, toxins produced by microorganisms, physical trauma and strong emotional reactions.⁽¹⁾

Some basic control mechanisms are geared toward counteracting the everyday stresses of life. However, if stress is extreme, unusual or long-lasting, these control mechanisms, can be quite harmful.⁽¹⁾ Conditions strongly linked to psychological stress include:^(1,2)

• Angina
• Asthma
• Autoimmune Diseases
• Irritable Bowel Syndrome
• Cancer
• Cardiovascular Disease
• Premenstrual Tension Syndrome
• Common Cold
• Rheumatoid Arthritis
• Diabetes, Type II
• Ulcerative Colitis
• Depression
• Ulcers
• Headaches
• Immune Suppression
• Menstrual Irregularities

Stress triggers a number of biological changes known collectively as the general adaptation syndrome. The three phases of the general adaptation syndrome are alarm, resistance and, finally, exhaustion. These phases are controlled and regulated by the adrenal glands.⁽¹⁾

The adrenal glands are responsible for maintaining the balance of many bodily functions by secreting several important hormones including those which effect:⁽¹⁾

• The Sympathetic Nervous System
• Glucose Metabolism
• Mineral Balance
• Sexual Function

An abnormal adrenal response, either deficient or excessive hormone secretion, significantly alters an individual's response to stress. Often the adrenals become "exhausted" as a result of the constant demands placed upon them. An individual with adrenal exhaustion may feel "stressed out", tired and be prone to allergies, while an individual with excessive adrenal activity is likely to have high blood pressure, anxiety, depression and elevated blood sugar and cholesterol levels.⁽¹⁾

Low levels of adrenal hormones have been found in patients with Chronic Fatigue Syndrome and in patients with depressive symptoms.⁽⁵⁾

Adreno Plus contains raw adrenal concentrate along with pantothenic acid to nourish and balance overactive or exhausted adrenal glands.

Pantothenic acid is particularly important for optimum adrenal function. Pantothenic acid deficiency results in adrenal atrophy, characterized by fatigue, headache, sleep disturbances, nausea and abdominal discomfort.^(1,4)

Glandular concentrates from healthy glands have been found beneficial for growth, repair and balance of weak or malfunctioning glands because they contain naturally occurring minerals, vitamins, enzymes, nucleo-proteins (RNA/DNA) and tissue-activating proteins which are specific to that particular gland.(3) Glandular therapy practitioners believe that raw tissues from animal sources contain intrinsic factors that are distinct from vitamins, minerals, hormones or enzymes. By feeding a patient these substances, many miraculous responses are noted.(6)

The DNA of each tissue contains specific amino acids in specific percentages and arrangements. When the blood contains amino acids in the proper balance and quality for a specific gland or tissue, it is easier for that particular gland to attain the amino acids necessary for repair and rebuilding. It is a matter of quality and quantity of available nutrients for any particular tissue or gland. If they are available in the blood qualitatively, the responding tissue or gland can rebuild or repair itself more readily according to the DNA pattern.(3)

In 1958 and again in 1972, Dr. A. Kemet documented through radioactive isotope tracing, that factors from glandular tissues are taken up by the bloodstream and absorbed by corresponding glands in the recipient. This research was done with injectable glandulars; however, most doctors believe equal results can be obtained from glandulars in tablet or capsule form.(6) There is evidence that some protein molecules are capable of passing intact through the intestinal system remaining in active form rather than being broken into amino acids for reassembly.(6,7)

Glandulars are not hormones. They activate the gland to produce hormones. The entire point of glandular therapy is to normalize the affected gland or tissue, not to stimulate it.

The adrenal glands lie just above the kidneys and are composed of two distinct parts, the adrenal medulla and the adrenal cortex. The inner portion of the adrenal gland, the medulla, is functionally related to the sympathetic nervous system, and secretes the hormones adrenalin (epinephrine) and noradrenaline (norepinephrine). These hormones stimulate many body processes related to the fight or flight response. They also serve to maintain normal nervous control over many involuntary bodily functions such as heart rate, respiration, digestion, etc.⁽¹⁾

The outer layer of the adrenal gland, the cortex, secretes an entirely different group of hormones called corticosteroids. These hormones are all formed from cholesterol. Although all corticosteroids have similar chemical formulas, they differ in function. The three major types of corticosteroids are mineral corticoids, glucocorticoids and 17-ketosteroids (sex hormones).⁽¹⁾

The glucocorticoids, mainly cortisol, corticosterone and cortisone, exert a profound effect upon the metabolism of glucose. These hormones can increase serum glucose levels and induce a state very similar to diabetes. These hormones also exert a catabolic effect on skin, muscle and fat. Medically, cortisone and other glucocorticoids are used to suppress the immune system in the treatment of allergies and to reduce inflammation.⁽¹⁾

The mineral corticoids, of which aldosterone is the most important, have profound effects on minerals. Specifically, aldosterone increases the retention of sodium and the excretion of potassium.⁽¹⁾

The 17-ketosteroids (sex hormones) are also secreted by the adrenals. The primary hormone produced by the adrenal is the androgen, dehydroepiandrosterone (DHEA) which has received attention as a possible anti-aging hormone.⁽¹⁾

Due to the importance of the adrenal gland, optimum health is dependent on optimum adrenal function. Atrophy or shrinking of the adrenal cortex is a common side effect of continual stress, cortisone administration and aging.^(1,2)

Adreno Plus supplies raw glandular substance important for repairing, rebuilding and balancing adrenal function along with the essential pantothenic acid.

In addition, vitamin C, vitamin B-6, zinc and magnesium are necessary for production of adrenal hormones. It is also critical to maintain potassium levels within the body.⁽¹⁾

The herb ginseng, an adaptogen, has also been shown to improve reactions against a variety of stresses. Much of ginseng's adaptogenic and anti-stress activity relates to its influence on the adrenal gland.⁽¹⁾

WARNING:   This publication and the product contained herein have not been approved or evaluated by the Food and Drug Administration. This publication, and the product contained herein are not intended to diagnose, treat, cure or prevent any disease. The product relates to nutritional support only.

1. Murray, M,  Pizzorno, J, Encyclopedia of Natural Medicine, Prima Publishing, Rocklin, CA,1991.

2. Seyle, H, Stress in Health and Disease, Butterworths, London, 1976.

3. Nittler, A, "The Use of Tissue and Glandular Substances", Journal of the National Academy of Nutritional Consultants, Vol.1, No. 1.

4. Nutrition Foundation, Present Knowledge in Nutrition, 5th ed., Washington, DC, 1984.

5. Demitrack, M.A., et al, "Evidence for Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndrome", Journal of Clinical Endocrinology and Metabolism, 1991;73:1224-34.

Product No. 958 Fill Size: 100 Capsules
Product No. 9582 Fill Size: 250 Capsules

Each capsule contains: % Daily Value
Pantothenic Acid (as d-calcium pantothenate) 50 mg. 500%
Raw Bovine Adrenal Concentrate 80 mg. *
Other ingredients: rice flour, magnesium stearate, gelatin. * Daily Value not established.

This natural product is prepared by a special process which does not exceed physiological temperature (37°C). Guaranteed to be free of chemical pesticides and synthetic hormones.

Recommended Use: One capsule three times daily.
Product 958,  100 capsules
Price:  $14.00